1 04-BioReview


1.1 Audio-recording

1.2 Opening thought

“We are survival machines,
robot vehicles blindly programmed to preserve the selfish molecules known as genes.
This is a truth which still fills me with astonishment.”

- Richard Dawkins, The Selfish Gene
- https://en.wikipedia.org/wiki/Gene-centered_view_of_evolution

1.3 Reading

At minimum, if you don’t know biology well, read these reviews:
https://www.nature.com/scitable/topicpage/biological-complexity-and-integrative-levels-of-organization-468/
https://www.nature.com/scitable/topicpage/mendelian-genetics-patterns-of-inheritance-and-single-966/
https://www.nature.com/scitable/topicpage/gene-interaction-and-disease-987/
https://www.nature.com/scitable/topicpage/translation-dna-to-mrna-to-protein-393/
https://www.nature.com/scitable/topicpage/what-is-a-gene-colinearity-and-transcription-430/
https://www.nature.com/scitable/topicpage/genetics-of-dog-breeding-434/
https://www.nature.com/scitable/topicpage/reading-a-phylogenetic-tree-the-meaning-of-41956/
https://www.nature.com/scitable/ebooks/cntNm-16553748/contents/
https://www.nature.com/scitable/topicpage/sexual-reproduction-and-the-evolution-of-sex-824/
https://www.nature.com/scitable/topicpage/genetic-mutation-1127/
https://readiab.org/biological-information.html

Read more of this free book if you need/want:
https://www.ncbi.nlm.nih.gov/books/NBK21128/

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1.4 Zoom through a big picture on biology…

04-BioReview/04-BioReview.html

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Discussion question
Genes can be thought of as a kind of:
memory for past enviroment, a memory of design space,
a biological programming language, an encoding.
Evolution and development is a process of learning from the environment.
We can “program” this space with a variety of methods,
direct (genetic engineering and gene therapy) and indirect (directed selection).
Why is it that direct genetic manipulation seems riskier than directed selection,
for example of food like apple trees or chickens?
Can you think of different costs and benefits?

Selfish genetic elements:
https://en.wikipedia.org/wiki/Selfish_genetic_element

Epigenetics as control of development, parental genomic imprinting, trans-generational inheritance?
https://en.wikipedia.org/wiki/Genomic_imprinting

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To see how this little presentation was made, see:
http://sozi.baierouge.fr/